When oral vitamin K 1 is used for warfarin reversal, the injectable formulation of vitamin K 1 is preferable to tablets because of its flexible dosing this formulation can be given orally or injected. Vitamin K 1 is essential for sustaining the reversal achieved by PCC and FFP. Immediate reversal is achieved with a prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP). To reverse the effects of warfarin, vitamin K 1 can be given. Risk factors for bleeding complications with warfarin use include age, history of past bleeding and specific comorbid conditions. Statistics,epidemiology and research designįor most warfarin indications, the target maintenance international normalised ratio (INR) is 2–3.Statistics, epidemiology and research design.
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